Myocardial Depressant Effects of Desflurane

Effects of desflurane and sevoflurane on length-dependent regulation of myocardial function in coronary surgery patients.

BACKGROUND Desflurane and sevoflurane have negative inotropic effects. The current study investigated whether these effects resulted in an altered left ventricular response to increased cardiac load and affected length-dependent regulation of myocardial function. Length-dependent regulation of myocardial function refers to the ability of the heart to improve its performance when preload is incr...

A circulating myocardial depressant substance in septic shock.

A Circulating Myocardial Depressant Substance in Humans with Septic Shock

We have previously described a subpopulation of patients with septic shock who had a reversible depression of radionuclidedetermined left ventricular ejection fraction (EF). To investigate the mechanism of this myocardial depression, an in vitro model of mammalian myocardial cell performance was established employing primary spontaneously beating rat myocardial cells. The contraction of a singl...

Effects of desflurane in senescent rat myocardium.

BACKGROUND The myocardial negative inotropic effects of desflurane are less pronounced than those of other halogenated anesthetics, partly because of intramyocardial catecholamine store release. However, the effects of desflurane on aging myocardium are unknown, whereas aging is known to be associated with an attenuation of catecholamine responsiveness. METHODS The effects of desflurane (1.9-...

Periodic asystole following myocardial infarction and cardiac depressant drugs.